Related Experiment Video
Updated: Jan 22, 2026
07:05
Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet
Published on: January 3, 2017
9.3K
Piperine: Old Spice and New Nutraceutical?
Katarina Smilkov1, Darinka G Ackova1, Aleksandar Cvetkovski1
1Department of Pharmacy, Faculty of Medical Sciences, Goce Delcev University, Stip, North Macedonia.
Current Pharmaceutical Design
|July 4, 2019
Summary
Piperine, a compound in pepper fruits, enhances nutrient bioavailability and exhibits anticancer and antioxidant properties. Research is exploring its molecular actions and therapeutic potential, aiming to overcome its low bioavailability.
Area of Science:
- Pharmacology
- Natural Products Chemistry
- Nutraceuticals
Background:
- Piperine is the primary active compound in pepper fruits.
- Its properties are linked to various biological activities.
Purpose of the Study:
- To review piperine's chemistry and physiological effects.
- To summarize its role as a bioenhancer.
- To present data on its toxicity, antioxidant, and anticancer activities.
Main Methods:
- Literature review of existing studies on piperine.
- Analysis of documented interactions and properties.
- Evaluation of reported toxicity and efficacy data.
Main Results:
- Piperine enhances bioavailability of drugs and nutraceuticals (e.g., curcumin).
- It exhibits dose-dependent and tissue-specific immunomodulating, antioxidant, chemopreventive, and anticancer effects.
- Low bioavailability is a limitation, but innovative formulations are addressing this.
Conclusions:
- Future research will focus on piperine's molecular mechanisms and bioavailability enhancement.
- Understanding piperine's action will clarify its therapeutic applications.
- Piperine is poised to be recognized as a significant nutraceutical.
