Related Experiment Video
Updated: Jan 22, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
[Folate deficiency as a differential diagnosis to severe pre-eclampsia]
Yagmur Sisman1, Rasmus Heje Thomsen, Vibeke Vestermark
1sismanyagmur@gmail.com.
Abstract:
In this case report, a 26-year-old pregnant woman presented with headache, visual disturbances, mega-loblastic anaemia, thrombocytopenia and proteinuria in her third trimester. These symptoms were initially misinterpreted as HELLP-syndrome, but due to normal blood pressure and liver function the patient was diagnosed with severe folate deficiency despite her daily supplements of folate to avoid neural tube defects and deficiency. The reason was onset of coeliac disease during pregnancy. Careful examination may help discriminate HELLP-syndrome from folate deficiency and thus avoid preterm delivery.
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