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Updated: Jan 22, 2026
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
Published on: June 7, 2018
A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System.
Brent R Stockwell1, Xuejun Jiang2
1Department of Biological Sciences, Columbia University, New York, NY 10027, USA; Department of Chemistry, Columbia University, New York, NY 10027, USA.
Ferroptosis, a cell death form, plays a role in cancer prevention. Interferon gamma from CD8+ T cells triggers ferroptosis, suppressing tumor growth during immune checkpoint blockade therapy.
Area of Science:
- Cellular biology
- Immunology
- Cancer research
Background:
- Ferroptosis is regulated cell death driven by phospholipid peroxidation.
- The immune system's role in preventing cancer is an active area of research.
Purpose of the Study:
- To investigate the role of ferroptosis in anti-tumor immunity.
- To understand the mechanism by which interferon gamma exerts tumor suppressive effects.
Main Methods:
- Investigated ferroptosis as a mediator of CD8+ T cell anti-tumor activity.
- Examined the function of interferon gamma in the context of immune checkpoint blockade.
Main Results:
- Ferroptosis mediates the tumor suppressive activity of interferon gamma.
- Interferon gamma is secreted by CD8+ T cells in response to immune checkpoint blockade.
- This suggests a mechanism for immune-mediated tumor suppression via ferroptosis.
Conclusions:
- The immune system utilizes ferroptosis to prevent tumorigenesis.
- Ferroptosis is a key pathway in anti-tumor immune responses.
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14:01Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
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