In Situ Oxidation of Cu₂O Crystal for Electrochemical Detection of Glucose

The development of a sensitive, quick-responding, and robust glucose sensor is consistently pursued for use in numerous applications. Here, we propose a new method for preparing a Cu₂O electrode for the electrochemical detection of glucose concentration. The Cu₂O glucose electrode was prepared by in situ electrical oxidation in an alkaline solution, in which Cu₂O nanoparticles were deposited on the electrode surface to form a thin film, followed by the growth of Cu(OH)₂ nanorods or nanotubes. The morphology and electrocatalytic activity of a Cu₂O glucose electrode can be tuned by the current density, reaction time, and NaOH concentration. The results from XRD, SEM, and a Raman spectrum show that the electrode surface was coated with cubic Cu₂O nanoparticles with diameters ranging from 50 to 150 nm. The electrode exhibited a detection limit of 0.0275 mM, a peak sensitivity of 2524.9 μA·cm^-2·mM^-1, and a linear response range from 0.1 to 1 mM. The presence of high concentrations of ascorbic acid, uric acid, dopamine and lactose appeared to have no effects on the detection of glucose, indicating a high specificity and robustness of this electrode.