Related Experiment Video

Updated: Jan 22, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.5K

The perioperative effect of magnesium sulfate in patients with concentric left ventricular hypertrophy undergoing

Rabie Soliman1, Walid Abukhudair2

  • 1Department of Anesthesia, Cairo University, Cairo, Egypt; Department of Cardiac Anesthesia, Cardiac Center, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia.

Annals of Cardiac Anaesthesia
|July 6, 2019
PubMed

Insights

Magnesium sulfate offers cardioprotection in cardiac surgery patients with left ventricular hypertrophy. This treatment reduced myocardial infarction and arrhythmia incidence, along with the need for circulatory support.

Area of Science:

  • Cardiology
  • Anesthesiology
  • Cardiovascular Surgery

Background:

  • Left ventricular concentric hypertrophy presents unique challenges during cardiac surgery.
  • Perioperative myocardial injury and arrhythmias are significant concerns in these patients.
  • Magnesium sulfate is explored for its potential cardioprotective properties.

Purpose of the Study:

  • To evaluate the cardioprotective effect of magnesium sulfate in patients with left ventricular concentric hypertrophy undergoing cardiac surgery.
  • To assess the impact of magnesium sulfate on myocardial injury markers and hemodynamic parameters.

Main Methods:

  • A double-blinded randomized controlled trial was conducted with 250 patients.
  • Patients were divided into two groups: one receiving magnesium sulfate infusion and the other receiving normal saline.
  • Key measurements included cardiac biomarkers (troponin I, CK-MB), ECG, echocardiographic parameters, and hemodynamic variables.

Main Results:

  • Magnesium sulfate group showed significantly lower troponin I, CK-MB levels, and ECG changes compared to the control group.
  • Improvements in diastolic function (E/A peak ratio) and end-diastolic volume were observed with magnesium sulfate.
  • Enhanced cardiac index and reduced heart rate, pulmonary artery pressure, and need for circulatory support were noted.

Conclusions:

  • Magnesium sulfate demonstrates a significant cardioprotective effect in patients with concentric ventricular hypertrophy undergoing cardiac surgery.
  • It effectively decreases the incidence of perioperative myocardial infarction and arrhythmias.
  • The use of magnesium sulfate reduces the requirement for pharmacological and mechanical circulatory support.
Abstract

Keywords:
Adult cardiac surgeryconcentric ventricular hypertrophycreatinine kinase-MB isoenzymemagnesium sulfatemyocardial protectiontroponin I

More Related Videos

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy08:34

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

Published on: September 25, 2017

25.4K
Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension04:49

Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension

Published on: June 14, 2024

1.2K

Related Concept Videos

Blind Procedures02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.4K
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
618
Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
3.8K
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
241
Sulfate Attack on Concrete01:29

Sulfate Attack on Concrete

Sulfate attack on concrete is a deterioration process characterized by a whitish discoloration beginning at the edges and corners, accompanied by cracking and spalling. This phenomenon occurs when sulfates react with the components of hardened concrete, forming compounds like calcium sulfate and calcium sulfoaluminate which occupy more space than the substances they replace, causing the concrete to expand and disrupt.
Sulfates from sources like soil, groundwater, or industrial effluents...
710
Random Error01:04

Random Error

Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.1K