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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Advances in brain imaging in multiple sclerosis.

Rosa Cortese1, Sara Collorone2, Olga Ciccarelli1

  • 1Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, UK.

Therapeutic Advances in Neurological Disorders
|July 6, 2019
PubMed
Summary
This summary is machine-generated.

Advanced brain imaging techniques like magnetic resonance imaging (MRI) are crucial for diagnosing and monitoring multiple sclerosis (MS). MRI reveals the complex nature of MS pathogenesis and aids in tracking treatment responses and neurodegeneration in clinical trials.

Keywords:
braindiagnosismagnetic resonance imagingmultiple sclerosispathogenesisprogression

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Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Brain imaging, particularly magnetic resonance imaging (MRI), is vital for multiple sclerosis (MS) diagnosis and progression monitoring.
  • The role of MRI in MS extends beyond clinical use, aiding in understanding the disease's complex pathogenesis.
  • MS is now viewed as a heterogeneous central nervous system disorder, not just focal white matter demyelination.

Purpose of the Study:

  • To review recent advancements in brain neuroimaging for multiple sclerosis (MS).
  • To bridge the gap between research findings and clinical applications of advanced imaging techniques in MS.
  • To highlight the utility of MRI biomarkers in assessing disease activity and neurodegeneration.

Main Methods:

  • Review of current literature on advanced brain imaging techniques in MS research.
  • Analysis of MRI biomarker applications for disease monitoring and clinical trials.
  • Synthesis of findings from research settings to clinical practice.

Main Results:

  • Advanced imaging techniques reveal the heterogeneous nature of MS pathogenesis in vivo.
  • MRI biomarkers show greater sensitivity to disease activity than clinical measures in relapsing-remitting MS.
  • Neurodegeneration markers from MRI hold promise for clinical trials in progressive MS phenotypes.

Conclusions:

  • Brain neuroimaging, especially MRI, is indispensable for understanding and managing MS.
  • MRI biomarkers offer sensitive tools for monitoring treatment efficacy and disease progression.
  • Continued research in neuroimaging will enhance both the understanding and clinical management of MS.