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Related Experiment Video

Updated: Jan 22, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
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Renal Denervation: Is It Ready for Prime Time?

Lucas Lauder1, Milan A Wolf2, Sean S Scholz2

  • 1Klinik für Innere Medizin III, Kardiologie, Angiologie, Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Saarland University Medical Center and Saarland University, 66421, Homburg, Saar, Germany. lucas.lauder@uks.eu.

Current Cardiology Reports
|July 7, 2019
PubMed
Summary
This summary is machine-generated.

Renal denervation (RDN) trials show blood pressure-lowering efficacy, confirming its potential. Future research must focus on long-term safety and efficacy in larger patient groups.

Keywords:
Device-based therapyHypertensionInterventional cardiologyRenal denervation

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Area of Science:

  • Interventional Cardiology
  • Hypertension Management

Background:

  • Renal denervation (RDN) is an evolving interventional cardiology field.
  • Early trials generated excitement, followed by scrutiny after the SYMPLICITY HTN-3 trial.

Purpose of the Study:

  • To provide an updated overview of current renal denervation trials.
  • To offer an outlook on the future of renal denervation therapies.

Main Methods:

  • Review of recent sham-controlled trials, including SPYRAL HTN and RADIANCE HTN.
  • Analysis of trial outcomes regarding blood pressure reduction and patient adherence.

Main Results:

  • Second-generation sham-controlled trials confirmed the blood pressure-lowering efficacy of RDN.
  • Patient non-adherence to medication and need for response predictors were highlighted.

Conclusions:

  • RDN has demonstrated proof-of-principle for blood pressure reduction.
  • Larger trials are necessary to evaluate the long-term safety and efficacy of RDN.