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Updated: Jan 22, 2026

An Innovative Method for Exosome Quantification and Size Measurement
Published on: January 17, 2015
Exosome manufacturing status
William Whitford1, Peter Guterstam2
1Strategic Solutions Leader, GE Healthcare, BioProcess, Cell Culture, Logan, UT, USA.
Abstract:
Exosomes are secreted by mammalian cells and are widely distributed in cellular systems. They are a medium of information and material transmission. The complexity of exosome nature and function is not thoroughly understood. Nevertheless, they are being confirmed as mediators of intercellular communication and play significant roles in many physiological and pathological processes. Significant obstacles to the efficient and robust isolation of large quantities of pure and specific exosomes still exist. These include a lack of understanding of the relationship between exosome characteristics and function, and a shortage of scalable solutions to separate specific exosomes from other large entities remain. Hence, generic production platforms are desired. While solutions suitable for exosome manufacturing under GMP are available, most have been developed for other purposes.
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