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Enhancement of Cell-Based Vaccine Manufacturing through Process Intensification.

William Whitford¹, Alain M SourabiÈ², Dushyant B Varshney

¹DPS Group, 959 Concord St #100, Framingham, MA 01701; and William.whitford@dpsgroupglobal.com.

PDA Journal of Pharmaceutical Science and Technology

|July 20, 2021

Summary

This summary is machine-generated.

Vaccine manufacturing process intensification accelerates vaccine development and approval. This field integrates novel technologies to improve efficiency, reduce costs, and enhance pandemic response for diverse vaccine types.

Keywords:

Intensification digital efficiency manufacturing optimization process production vaccine

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Area of Science:

Biotechnology
Pharmaceutical Manufacturing
Process Engineering

Background:

The COVID-19 pandemic accelerated vaccine development and highlighted the need for advanced manufacturing. Vaccine manufacturing process intensification emerged as a critical discipline.
Diverse vaccine types (conjugate, hybrid, nucleic acid-based) and manufacturing platforms (fermentation, cell culture, plant-based) present unique challenges.

Purpose of the Study:

To review recent advances in vaccine manufacturing process intensification.
To highlight key technologies and processes driving efficiency and cost-effectiveness in vaccine production.

Main Methods:

Exploration of novel prophylactic vaccine modalities and biopharmaceutical process intensification.
Integration of disciplines like synthetic biology, process simplification, continuous bioprocessing, and digital techniques.
Focus on advances in process development, manufacturing platforms, materials, equipment, and facility design.

Main Results:

Significant acceleration in vaccine development and approval, including novel modalities.
Increased appreciation and understanding of vaccine manufacturing processes.
Growing interest in applying new technologies for biopharmaceutical process intensification.

Conclusions:

Vaccine manufacturing process intensification is crucial for cost control, efficiency, and pandemic preparedness.
Advances in equipment, technology, and processes are vital for optimizing vaccine production.
Interdisciplinary approaches are key to overcoming challenges in diverse vaccine manufacturing.