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Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies
Published on: May 19, 2022
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Digital biomanufacturing supporting vascularization in 3D bioprinting
William Whitford1, James B Hoying2
1BioProcess, GE Healthcare Life Sciences, 925 West 1800 South, Logan, UT 84321, USA.
International Journal of Bioprinting
|October 23, 2020
Summary
Bioprinting is advancing from simple methods to complex, multi-material constructs with integrated vascular networks. This evolution enables real-time process optimization and improved decision-making for tissue engineering.
Area of Science:
- Bioprinting technologies
- Tissue engineering
- Biofabrication
Background:
- Bioprinting research is consolidating, moving beyond basic operations.
- Current efforts focus on multi-material deposition and advanced bioink development.
Purpose of the Study:
- To highlight the synergistic advancements in bioprinting technology.
- To discuss the integration of vascular components in tissue constructs.
- To explore the impact of data management and process control on bioprinting.
Main Methods:
- Development of multi-modal deposition techniques for interpenetrating networks.
- Design of specialized bioinks addressing critical process parameters.
- Integration of monitoring and control instruments for real-time data collection.
Main Results:
- Emergence of model-controlled, multi-material bioprinting.
- Advances in architectural design for vascularization in tissue constructs.
- Creation of interconnected "process networks" for enhanced data analysis and decision-making.
Conclusions:
- Synergistic progress in bioprinting is leading to more sophisticated tissue constructs.
- Real-time optimization of bioprocesses is achievable through integrated data management and control.
- Supervisory enterprise control is being implemented for end-to-end bioprinting operations.
