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Updated: Jan 22, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Isodesmic C-H Borylation: Perspectives and Proof of Concept of Transfer Borylation Catalysis
Étienne Rochette1, Vincent Desrosiers1, Yashar Soltani1
1Département de Chimie , Université Laval , 1045 Avenue de la Médecine , Québec City , Québec G1V 0A6 , Canada.
Abstract:
The potential advantages of using arylboronic esters as boron sources in C-H borylation are discussed. The concept is showcased using commercially available 2-mercaptopyridine as a metal-free catalyst for the transfer borylation of heteroarenes using arylboronates as borylation agents. The catalysis shows a unique functional group tolerance among C-H borylation reactions, tolerating notably terminal alkene and alkyne functional groups. The mechanistic investigation is also described.
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