18F-NaF Uptake in Ocular Prosthesis (Implant).
Esha Kothekar1, Siavash Mehdizadeh Seraj, Fatemeh Kaghazchi
1From the Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA.
Clinical Nuclear Medicine
|July 9, 2019
Summary
An ocular prosthesis made of polymethyl methacrylate showed increased F-NaF uptake on PET/CT scans. This incidental finding in a prostate cancer patient highlights potential imaging artifacts in ocular implants.
Area of Science:
- Ophthalmology and Nuclear Medicine
- Radiopharmaceutical Imaging
- Biomaterials Science
Background:
- Ocular prostheses replace eyes after surgical removal (enucleation/evisceration).
- Common materials include polymethyl methacrylate (PMMA), hydroxyapatite (HA), and porous polyethylene (PP).
- Fluoride-NaF PET/CT is used for detecting bone metastases in cancers like prostate cancer.
Observation:
- An 82-year-old man with prostate cancer underwent F-NaF PET/CT imaging.
- The imaging incidentally revealed increased sodium fluoride (NaF) uptake within the patient's ocular prosthesis.
- The prosthesis material was identified as polymethyl methacrylate (PMMA).
Findings:
- The ocular prosthesis demonstrated abnormal F-NaF accumulation.
- This finding was incidental during a scan for metastatic bone disease.
- The increased uptake suggests potential interaction between NaF and PMMA materials.
Implications:
- Ocular prosthesis material can influence radiotracer uptake in PET/CT imaging.
- This highlights a potential source of false positives in oncologic imaging.
- Awareness is crucial for accurate interpretation of F-NaF PET/CT scans in patients with ocular implants.
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