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[The preliminary development of reference values of carotid artery intima-media thickness in children aged 6-11

L Yang1, X N Zong2, Q Liu3

  • 1Department of Epidemiology, School of Public Health, Shandong University/Children Cardiovascular Research Center of Shandong University, Jinan 250012, China.

Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]
|July 10, 2019
PubMed

Insights

This study establishes crucial reference values for carotid intima-media thickness (cIMT) in Chinese children aged 6-11. These findings provide essential benchmarks for assessing pediatric cardiovascular health.

Area of Science:

  • Pediatric Cardiology
  • Vascular Health
  • Biometrics

Background:

  • Establishing normative data for vascular parameters in pediatric populations is essential for early detection of cardiovascular risks.
  • Carotid intima-media thickness (cIMT) is a sensitive indicator of subclinical atherosclerosis.
  • Reference values for cIMT in Chinese children are currently limited.

Purpose of the Study:

  • To develop age-specific and sex-specific reference values for carotid intima-media thickness (cIMT) in Chinese children aged 6-11 years.
  • To provide normative data for cIMT that can be used in clinical and research settings.
  • To establish percentile curves for cIMT using the LMS method.

Main Methods:

  • A cross-sectional survey was conducted involving 1,033 Chinese children aged 6-11 years.
  • Children with obesity or hypertension were excluded from the study.
  • Percentile curves for cIMT were generated using the lambda, mu, and sigma (LMS) method.

Main Results:

  • Sex-specific and age-specific reference values (P90 and P95) for mean, left, and right cIMT were established.
  • cIMT percentile values demonstrated an increasing trend with age.
  • For a given age and percentile, boys exhibited higher cIMT values compared to girls.

Conclusions:

  • This study successfully developed comprehensive cIMT percentile reference values for Chinese children aged 6-11.
  • The established reference values are specific to sex and age, offering a valuable tool for pediatric cardiovascular assessment.
  • These findings contribute to the understanding of normal vascular development in children.

Keywords:
Carotid intima-media thicknessChildCross-sectional studiesReference values

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