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[Recommendations for vaccination against ROTAvirus in PREMature newborns (ROTAPREM)]

Javier Álvarez Aldeán1, Susana Ares Segura2, Celia Díaz González2

  • 1Unidad Neonatal, Hospital Costa del Sol, Marbella, Málaga, España; Sociedad Española de Neonatología, España; Comité Asesor de Vacunas de la Asociación Española de Pediatría, España.

Anales De Pediatria
|July 11, 2019
PubMed

Insights

Rotavirus (RV) vaccines are safe and effective for preterm infants, offering crucial protection against severe gastroenteritis. Vaccination during hospitalization minimizes risks and aligns with their care needs.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Vaccinology

Background:

  • Rotavirus (RV) is a primary cause of severe acute gastroenteritis in infants globally.
  • Most children contract RV by age five, particularly within the first two years of life.
  • Preterm infants face a higher risk of severe RV infection compared to full-term infants.

Purpose of the Study:

  • To evaluate the safety and efficacy of rotavirus vaccines in preterm infants.
  • To compare RV vaccination outcomes in preterm versus full-term infants.
  • To assess the risks of viral transmission associated with RV vaccination in hospitalized preterm infants.

Main Methods:

  • Analysis of data from rotavirus vaccination studies in preterm infants.
  • Comparison of vaccine effectiveness and safety profiles between preterm and full-term infants.
  • Evaluation of horizontal viral transmission risks during hospital-based vaccination.

Main Results:

  • Rotavirus vaccines demonstrate effectiveness and safety in preterm infants, comparable to full-term infants.
  • A marginal risk of horizontal viral transmission was observed when vaccination occurred during hospitalization.
  • Preterm infants often require hospitalization beyond 12 weeks of life, suggesting an opportune time for vaccination.

Conclusions:

  • Rotavirus vaccination is recommended for preterm infants to prevent severe gastroenteritis.
  • Hospitalization provides a suitable setting for administering RV vaccines to preterm infants according to immunization schedules.
  • Vaccination during hospitalization is safe and effective, with minimal risk of viral spread.

Keywords:
Acute gastroenteritisCoberturaCoverageGastroenteritis agudaImmunisationPrematurePrematuroRotavirusVacunación

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