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An Analytical Differential Resistance Pulse System Relying on a Time Shift Signal Analysis-Applications in Coulter

Peter R Birkin¹, Steven Linfield¹, Guy Denuault¹

¹Department of Chemistry , University of Southampton , Southampton , SO171BJ , United Kingdom.

|July 11, 2019

Summary

A new differential resistive pulse sensing (DiS) system enhances particle size detection sensitivity. This novel method uses a self-servoing regime for accurate measurements of particles translocating through microchannels.

Keywords:

Coulter differential microchannel sensitivity translocation

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Area of Science:

Biophysics
Nanotechnology
Analytical Chemistry

Background:

The Coulter counting technique is a widely used method for particle size analysis.
Improving the sensitivity and size range of detection enhances the technique's versatility.

Purpose of the Study:

To develop and test a novel differential resistive pulse sensing (DiS) system.
To increase the sensitivity and extend the detectable particle size range for resistive pulse sensing.

Main Methods:

A differential resistive pulse sensing (DiS) system was developed.
A time shift approach within a "self-servoing regime" was utilized to achieve zero background signal.
Polystyrene particles were translocated through a cylindrical glass microchannel (GMC) under a static pressure difference.

Main Results:

The DiS system demonstrated high sensitivity and accuracy in detecting and characterizing polystyrene particles.
An analytical response that scales with particle size was verified.
Millisecond timescale translocations were successfully detected.

Conclusions:

The developed DiS system significantly improves particle sizing sensitivity and range.
The self-servoing regime effectively eliminates background noise for accurate measurements.
This technique offers a versatile and accurate method for particle characterization.