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Nuclear Fusion02:45

Nuclear Fusion

33.7K
The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
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Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

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Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
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SNAREs and Membrane Fusion01:43

SNAREs and Membrane Fusion

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Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
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Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

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Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
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Phase Transitions: Melting and Freezing02:39

Phase Transitions: Melting and Freezing

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Heating a crystalline solid increases the average energy of its atoms, molecules, or ions, and the solid gets hotter. At some point, the added energy becomes large enough to partially overcome the forces holding the molecules or ions of the solid in their fixed positions, and the solid begins the process of transitioning to the liquid state or melting. At this point, the temperature of the solid stops rising, despite the continual input of heat, and it remains constant until all of the solid is...
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Hybrid Zones02:29

Hybrid Zones

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Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
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Related Experiment Video

Updated: Jan 22, 2026

Analysis of SNARE-mediated Membrane Fusion Using an Enzymatic Cell Fusion Assay
09:19

Analysis of SNARE-mediated Membrane Fusion Using an Enzymatic Cell Fusion Assay

Published on: October 19, 2012

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LisFranc Fusion.

Brandon Jonard1, Andrew Wroblewski, Jeffrey Junko

  • 1Summa Health Orthopaedic Institute, Akron, OH.

Journal of Orthopaedic Trauma
|July 11, 2019
PubMed
Summary
This summary is machine-generated.

Lisfranc injuries, often missed, require imaging like CT scans for diagnosis. This video demonstrates a tarsometatarsal joint fusion technique for acute Lisfranc injuries, addressing both ligamentous and bony types.

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Area of Science:

  • Orthopedic Surgery
  • Traumatology
  • Radiology

Background:

  • Lisfranc injuries are often overlooked and can occur in isolation or with polytrauma.
  • Accurate diagnosis may necessitate weight-bearing X-rays or advanced imaging like CT scans.
  • Fusion is indicated for ligamentous injuries, chronic cases, or post-traumatic arthritis, with primary fusion an option for acute fractures.

Observation:

  • The video presents a surgical technique for tarsometatarsal joint fusion.
  • This procedure is specifically demonstrated for acute Lisfranc injuries.
  • The technique is applicable to both ligamentous and bony Lisfranc injury variants.

Findings:

  • The demonstrated technique aims to achieve midfoot stability.
  • Restoration of the anatomical arch and cascade is a primary surgical goal.
  • This fusion method offers an alternative to traditional open reduction internal fixation for acute fractures.

Implications:

  • This video serves as a valuable educational resource for surgeons managing Lisfranc injuries.
  • The presented technique may improve outcomes for patients with acute Lisfranc injuries.
  • Understanding and applying this fusion technique can enhance midfoot stability and function post-injury.