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Prognostic Implications of Diastolic Dysfunction Change in Patients With Coronary Artery Disease Undergoing

Eun Kyoung Kim1, Joo-Yong Hahn1, Taek Kyu Park1

  • 1Division of Cardiology, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine.

Circulation Journal : Official Journal of the Japanese Circulation Society
|July 12, 2019
PubMed

Insights

Worsening diastolic function after percutaneous coronary intervention (PCI) significantly increases the risk of major adverse cardiac events (MACE). Monitoring changes in diastolic function post-PCI can predict long-term outcomes in these patients.

Area of Science:

  • Cardiology
  • Echocardiography
  • Interventional Cardiology

Background:

  • The prognostic impact of changes in diastolic function (DF) following percutaneous coronary intervention (PCI) remains unclear.
  • Diastolic dysfunction is prevalent in patients undergoing PCI.

Purpose of the Study:

  • To investigate the prognostic significance of alterations in diastolic dysfunction after PCI.
  • To determine if changes in DF predict long-term clinical outcomes in patients who have undergone PCI.

Main Methods:

  • Prospective inclusion of patients undergoing PCI with pre- and post-revascularization echocardiography.
  • Definition of Major Adverse Cardiac Events (MACE) as cardiac death, myocardial infarction, or repeat revascularization.
  • Analysis of 1,235 patients to assess DF changes and MACE risk.

Main Results:

  • Baseline diastolic dysfunction was observed in 83.6% of patients.
  • Diastolic function worsened in 17.8% of patients post-PCI.
  • Worsened DF was independently associated with a significantly higher risk of MACE (aHR: 2.15-2.20) compared to unchanged or improved DF, irrespective of systolic function.

Conclusions:

  • Aggravation of diastolic dysfunction post-PCI is an independent predictor of increased MACE risk.
  • Assessing DF changes after PCI offers a valuable tool for predicting long-term clinical outcomes.
Abstract

Keywords:
Coronary artery diseaseDiastolic dysfunctionPercutaneous coronary intervention

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