Differential functional patterns of the human posterior cingulate cortex during activation and deactivation: a
Jessica N Busler1,2,3,4, Julio A Yanes5,6,7,8, Ryan T Bird5,6,7,8
1Department of Psychology, Auburn University, 226 Thach Hall, Auburn, AL, 36849, USA. jbusler@auburn.edu.
Experimental Brain Research
|July 12, 2019
Summary
The posterior cingulate cortex (PCC) shows distinct activation and deactivation patterns, revealing its complex role in brain function and potential involvement in neurological disorders.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Brain Imaging
Background:
- The posterior cingulate cortex (PCC) is a key node in the default mode network (DMN) and is involved in numerous cognitive functions.
- PCC dysfunction is linked to various psychiatric and neurological disorders, but its specific functional states remain unclear.
Purpose of the Study:
- To delineate the specific functional activity patterns of the human PCC during activated and deactivated states.
- To investigate the differential connectivity of PCC subregions.
Main Methods:
- Utilized meta-analytical connectivity modeling (MACM) to identify co-activation and co-deactivation patterns.
- Employed ultra-high field, high-resolution resting-state functional magnetic resonance imaging (rs-fMRI) for connectivity analysis.
- Conducted exploratory analyses on dorsal and ventral PCC subregions.
Main Results:
- MACM identified convergent regions for PCC co-activation/deactivation (e.g., medial frontal gyrus, amygdala) and divergent regions specific to activation (inferior frontal gyri) or deactivation (parahippocampal gyrus).
- Dorsal PCC showed greater co-activation with the inferior parietal lobule, while ventral PCC co-activated with the precuneus.
- rs-fMRI revealed widespread connectivity mirroring PCC co-activation, with additional involvement of parietal and temporal regions.
Conclusions:
- The PCC exhibits a diverse neurofunctional repertoire with dynamic state-specific activity patterns.
- Findings offer insights into the PCC's role in cognitive processes and potential implications for clinical populations.
- This study enhances understanding of the PCC's functional organization and its dynamic nature.
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