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Hepatitis E Infection in HIV-Infected Patients
Antonio Rivero-Juarez1, Pedro Lopez-Lopez1, Mario Frias1
1Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Córdoba, Spain.
Frontiers in Microbiology
|July 13, 2019
Summary
Hepatitis E virus (HEV) causes acute hepatitis globally, with outbreaks in low-income nations and zoonotic links in high-income countries. Immunosuppression can alter HEV
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Background:
- Hepatitis E virus (HEV) is a significant cause of acute hepatitis worldwide.
- HEV outbreaks are common in low-income countries, linked to contaminated water and high mortality.
- In high-income countries, HEV is a zoonotic disease associated with food consumption.
Purpose of the Study:
- To review current knowledge on HEV infection in HIV-infected individuals.
- To cover epidemiology, diagnosis, clinical manifestations, management, and prevention.
- To highlight challenges faced by HIV-infected patients regarding HEV.
Main Methods:
- Literature review of HEV infection in HIV-infected subjects.
- Synthesis of current data on HEV epidemiology.
- Analysis of diagnostic and clinical aspects of HEV in immunocompromised populations.
Main Results:
- HEV infection presents unique challenges in HIV-infected individuals.
- Immunosuppression can significantly impact HEV pathogenesis and clinical outcomes.
- Understanding HEV in HIV is crucial for effective management.
Conclusions:
- Despite advances, significant factors remain for HIV-infected patients regarding HEV.
- Treatment recommendations, immunization, and risk practices require further attention.
- Further research is needed to optimize HEV care in the context of HIV.
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