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Traceless-Activation Strategy for Rh-Catalyzed Csp2-H Arylation of Coumarins
Fuzhong Han1, Shanshan Xun1, Lina Jia1
1College of Chemistry and Chemical Engineering , Qiqihar University , Qiqihar 161006 , China.
Abstract:
A traceless-activation strategy for the synthesis of 4-arylchroman-2-ones via a Rh(III)-catalyzed C-H activation of 2-arylpyridines and subsequent conjugated/decarboxylative addition to coumarin-3-carboxylic acids has been reported. The carboxyl group at C3 position of coumarin proved to be crucial to realize the reaction, which is spontaneously removed after the reaction by the release of CO2. The reaction displayed good substrate tolerance and gave various 4-arylchroman-2-ones in up to 90% yield.
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