Bleaching gel mixed with MI Paste Plus reduces penetration of H₂O₂ and damage to pulp tissue and maintains bleaching...

MI Paste Plus remineralizer (Rem) strengthens dental structures after bleaching. We investigated the effect of Rem on the penetration of hydrogen peroxide (H₂O₂), bleaching effectiveness, and pulp inflammation after bleaching.

Bovine disks were grouped as follows (n = 10): control (untreated), bleached (Ble; 35% H₂O₂, 30 min), Ble-Rem (H₂O₂ followed by Rem, 30 min), Rem-Ble (Rem followed by H₂O₂), Rem-Ble-Rem (Rem before and after H₂O₂), and Ble+Rem (mixture of Rem with H₂O₂, 1:1, 30 min). The penetration of H₂O₂ was quantified and bleaching efficacy was analyzed. Upper rat molars (n = 10) received the same treatments at random. The rats were euthanized after two days and 30 days, and their jaws were removed for histological analysis. Statistical tests were performed (P < 0.05).

The bleached groups, except Ble+Rem (P > 0.05), showed significant H₂O₂ penetration compared with control (P < 0.05). Color alteration analysis showed that ΔL and ΔE were significantly higher in the bleached groups than those in control (P < 0.05); the Δb of the bleached groups differed from that of control at 24 h (P < 0.05). At two days, necrosis or inflammation was observed in the bleached groups compared with control (P < 0.05), except Ble+Rem, which was similar to control (P > 0.05). At 30 days, tertiary dentin formation was significant in the bleached groups (P < 0.05), except Ble+Rem (P > 0.05).

The mixture of MI Paste Plus and bleaching gel reduces H₂O₂ penetration and pulp damage and maintains bleaching effectiveness.

Because bleaching can damage dental tissues, we studied a new bleaching protocol that reduces damage to the pulp tissue while maintaining bleaching efficiency: a single application of 30 min of MI Paste Plus mixed with 35% H₂O₂ bleaching gel (1:1).