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Updated: Jan 22, 2026

A Multimodal Wide-Field Fourier-Transform Raman Microscope
Published on: December 30, 2025
Probing stress induced phase transformation in aspirin polymorphs using Raman spectroscopy enabled nanoindentation
Praveena Manimunda1, S A Syed Asif1, Manish Kumar Mishra2
1Bruker Nano Surfaces, Eden Prairie, Minneapolis, Minnesota, USA. praveena.manimunda@gmail.com.
Abstract:
Nanoindentation has extensively been used to measure the mechanical properties of molecular crystals. However, the possibilities of stress induced polymorphic transformation during indentation are still unexplored. Here, we have adopted a spatially synchronized Raman spectroscopy and nanoindentation technique to probe indentation induced polymorphic transformation in aspirin polymorphs. Spatial hardness maps, generated using an accelerated property mapping technique, showed micro-domain formation in aspirin form II crystals.
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