Related Experiment Video
Updated: Jan 22, 2026
03:19
Author Spotlight: Advancing Varicocele Treatment with Neuromuscular Electrical Stimulation
Published on: August 30, 2024
1.2K
Olmesartan-induced enteropathy treated with budesonide
S Kempenaers1, J Bogaert2, M De Maeyer2
1Faculty of Medicine, University of Leuven, 3000 Leuven, Belgium.
Acta Gastro-Enterologica Belgica
|July 18, 2019
Summary
Olmesartan, an antihypertensive drug, can cause a rare condition called olmesartan-induced enteropathy. This case report suggests budesonide may be a potential treatment option for this condition.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Olmesartan is a widely prescribed angiotensin receptor blocker for hypertension.
- Seronegative villous atrophy, a condition affecting the small intestine, was linked to olmesartan use in 2012.
Observation:
- This report details a new case of olmesartan-induced enteropathy.
- The patient presented with symptoms consistent with drug-induced intestinal damage.
Findings:
- The case was compared with existing literature on olmesartan-induced enteropathy.
- Histopathological findings confirmed villous atrophy.
Implications:
- This case highlights the importance of considering drug-induced enteropathy in patients on olmesartan.
- Budesonide is proposed as a potential therapeutic agent for olmesartan-induced enteropathy, warranting further investigation.
Related Concept Videos
01:13Induced Pluripotent Stem Cells
27.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.3K
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
1.2K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.2K
01:13Induced-fit Model
88.9K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
88.9K
01:30Spontaneous and Induced Mutations
2.1K
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
2.1K
01:28Induced Electric Dipoles
4.7K
A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
Since the absolute value of potential energy holds no physical meaning, its zero value can be chosen as per...
Since the absolute value of potential energy holds no physical meaning, its zero value can be chosen as per...
4.7K
01:23Induced Electric Fields
4.6K
The fact that emfs are induced in circuits implies that work is being done on the conduction electrons in the wires. What can possibly be the source of this work? We know that it’s neither a battery nor a magnetic field, as a battery does not have to be present in a circuit where current is induced, and magnetic fields never do any work on moving charges. The source of the work is in fact an electric field that is induced in the wires. For example, if a stationary conductor is placed in a...
4.6K