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Author Spotlight: Establishing Mixed Neuronal and Glial Cell Cultures from Embryonic Mouse Brains to Study Infection and Innate Immunity
Published on: June 30, 2023
A Triad of Immune Cells Promotes Infection
Marco A Ataide1, Wolfgang Kastenmuller1
1Institute for Systems Immunology, Julius Maximilian University of Würzburg, Würzburg, Germany.
Abstract:
The intracellular pathogen L. monocytogenes takes advantage of several myeloid cell populations to establish infection in the spleen. In this issue, Liu et al. (2019) reveal how marginal zone B cells, dendritic cells, and marginal metallophilic macrophages act together with IL-10 to promote L. monocytogenes infection, while simultaneously enabling adaptive CD8+ T cell responses.
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