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Related Concept Videos

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

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Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
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Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

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Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
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Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

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Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
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Actin Polymerization01:42

Actin Polymerization

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Actin polymerization occurs through the head-to-tail association of binding sites on monomeric actin or G-actin to form filamentous or F-actin. The polymerization can be divided into three phases ̶  nucleation, elongation, and steady-state phase.
The nucleation phase involves forming a stable nucleus consisting of three actin monomers to form a new actin filament. Actin-binding proteins such as formins and Arp2/3 complex help filament growth post-nucleation. The Formins form straight...
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Protein Complex Assembly02:41

Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
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Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

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Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
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Related Experiment Video

Updated: Jan 22, 2026

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
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Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization

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Ring-opening metathesis polymerization-induced self-assembly (ROMPISA).

Spyridon Varlas1, Jeffrey C Foster1, Rachel K O'Reilly1

  • 1School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. J.C.Foster@bham.ac.uk R.OReilly@bham.ac.uk.

Chemical Communications (Cambridge, England)
|July 20, 2019
PubMed
Summary
This summary is machine-generated.

Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) offers a rapid, air-tolerant method for creating unique polymeric nanoparticles. This advanced technique simplifies nanoparticle synthesis, enhancing their commercial applications.

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Last Updated: Jan 22, 2026

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
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Ethylene Polymerizations Using Parallel Pressure Reactors and a Kinetic Analysis of Chain Transfer Polymerization
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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Polymerization-induced self-assembly (PISA) is a key technique for synthesizing polymeric nanoparticles.
  • Existing PISA methods can be complex and time-consuming.
  • There is a need for more efficient and versatile nanoparticle synthesis strategies.

Purpose of the Study:

  • To highlight recent advancements in ring-opening metathesis polymerization-induced self-assembly (ROMPISA).
  • To showcase ROMPISA as a powerful alternative to conventional PISA methods.
  • To emphasize the unique characteristics of nano-objects produced via ROMPISA.

Main Methods:

  • Utilizing ring-opening metathesis polymerization (ROMP) as the driving force for self-assembly.
  • Conducting polymerization under ambient air conditions.
  • Characterizing the resulting nano-object morphologies.

Main Results:

  • ROMPISA enables rapid nanoparticle formation, often within minutes.
  • The process can be performed under air, simplifying experimental setup.
  • Unique and tunable nano-object morphologies are achievable through ROMPISA.

Conclusions:

  • ROMPISA represents a significant advancement in PISA methodologies.
  • This technique offers a simplified and efficient route to polymeric nanoparticles.
  • The commercial importance of polymeric nanoparticles is likely to increase due to ROMPISA's advantages.