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Updated: Jan 22, 2026

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[SERUM CONTENTS OF SUBSTANCE P, ENDOTHELIN-1 AND VASOACTIVE INTESTINAL PEPTIDE IN CHILDREN WITH RECURRENT BRONCHITIS

T Slutskaya1, L Ovcharenko1, A Vertehel1

  • 1Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine, Ukraine.

Georgian Medical News
|July 20, 2019
PubMed

Insights

Children with recurrent bronchitis and vertebrobasilar arterial system syndrome show an imbalance of substance P, endothelin-1, and vasoactive intestinal peptide. This neurogenic imbalance contributes to the severe course of their bronchitis.

Area of Science:

  • Pediatric Pulmonology
  • Neuroscience
  • Immunology

Background:

  • Recurrent bronchitis (RB) pathogenesis involves impaired bronchial secretory-evacuation mechanisms.
  • Vegetative reflexes and neuropeptide imbalance can disrupt these mechanisms, particularly in children with syndrome of the vertebrobasilar arterial system (SVBAS).

Purpose of the Study:

  • To investigate the neurogenic mechanisms underlying recurrent bronchitis in children with SVBAS.
  • To analyze serum levels of substance P, vasoactive intestinal peptide (VIP), and endothelin-1 (ET-1) in relation to bronchial function and inflammation.

Main Methods:

  • A study involving 90 children aged 7-11 years, divided into three groups: RB with SVBAS, SVBAS without RB, and RB without SVBAS.
  • Serum levels of substance P, VIP, and ET-1 were measured and compared across the groups.

Main Results:

  • Children with both RB and SVBAS exhibited significantly higher serum levels of substance P and ET-1 compared to the other groups.
  • These children also showed significantly lower serum levels of VIP.
  • An imbalance of pro-inflammatory (substance P, ET-1) and anti-inflammatory (VIP) neuropeptides was observed in children with RB and SVBAS.

Conclusions:

  • Serum neuropeptide imbalance, specifically elevated substance P and ET-1 with reduced VIP, is a key factor in the pathogenesis of severe recurrent bronchitis in children with SVBAS.
  • This finding highlights the neurogenic component of RB in this pediatric population.

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