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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
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PLASMA MICRORNA-133А LEVEL IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION.

S Koval1, I Snihurska2, K Yushko2

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This summary is machine-generated.

Plasma miR-133a levels are significantly lower in patients with essential arterial hypertension (EAH) and left ventricular hypertrophy (LVH). This reduction suggests miR-133a plays a role in hypertension and cardiac remodeling.

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Area of Science:

  • Biochemistry
  • Cardiology
  • Molecular Biology

Background:

  • Essential arterial hypertension (EAH) is a widespread condition with significant cardiovascular implications.
  • MicroRNAs (miRNAs) are increasingly recognized as key regulators in cardiovascular disease pathogenesis.
  • Plasma miR-133a has been implicated in cardiac function and disease, but its specific role in EAH requires further elucidation.

Purpose of the Study:

  • To investigate the plasma microRNA (miR-133a) level in patients diagnosed with essential arterial hypertension (EAH).
  • To assess the correlation between plasma miR-133a levels and hypertension-mediated organ damage, particularly left ventricular hypertrophy (LVH).

Main Methods:

  • Quantitative analysis of plasma miR-133a levels using real-time polymerase chain reaction (PCR).
  • Comparison of miR-133a levels between 45 EAH patients and 21 healthy controls.
  • Assessment of risk factors and hypertension-mediated organ damage in the EAH cohort.

Main Results:

  • Patients with EAH exhibited significantly lower plasma miR-133a levels compared to healthy individuals.
  • A significant reduction in plasma miR-133a was observed in EAH patients with left ventricular hypertrophy (LVH) compared to those without LVH.
  • No significant differences in miR-133a levels were found based on the presence of other risk factors, organ damage, or cardiovascular diseases.

Conclusions:

  • Reduced plasma miR-133a levels are associated with essential arterial hypertension.
  • The decrease in miR-133a may contribute to the pathogenesis of hypertension and pathological cardiac remodeling, especially LVH.
  • Plasma miR-133a could serve as a potential biomarker for hypertension and associated cardiac changes.