QUANTITATIVE CHARACTERISTICS OF GUT MICROBIOTA IN PATIENTS WITH ARTERIAL HYPERTENSION

Area of Science:

• Microbiology
• Human Physiology
• Medical Science

Background:

• Arterial hypertension (AH) is a widespread cardiovascular disease.
• Gut microbiota (GM) composition is increasingly recognized for its role in metabolic and cardiovascular health.
• Understanding GM variations in specific populations with AH is crucial for targeted interventions.

Purpose of the Study:

• To quantitatively assess gut microbiota (GM) in Ukrainian patients with arterial hypertension (AH).
• To compare GM profiles of AH patients with those of healthy individuals.
• To identify specific bacterial groups associated with AH in this population.

Main Methods:

• Quantitative analysis of gut microbiota using polymerase chain reaction (PCR) with hybridization-fluorescence detection.
• Utilized the "COLONOFLOR-16 (biocenosis)" test system.
• Standard clinical, laboratory, and instrumental examinations were performed.

Main Results:

• Patients with AH exhibited significant differences in GM quantitative characteristics compared to healthy controls.
• A notable decrease in the abundance of Lactobacillus spp., Bifidobacterium spp., and Faecalibacterium prausnitzii was observed in AH patients.
• These specific bacterial deficiencies were consistent across the AH cohort.

Conclusions:

• The study identified a significant reduction in beneficial gut bacteria (Lactobacillus spp., Bifidobacterium spp., Faecalibacterium prausnitzii) in Ukrainian patients with arterial hypertension.
• Gut microbiota dysbiosis is implicated in the pathogenesis of hypertension.
• These findings highlight the potential role of GM modulation in managing AH.