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DETERMINATION OF THE SENSITIVITY OF GARDNERELLA VAGINALIS TO FENTICONAZOLE
P Fedorych1, T Kuts1, S Koval1
1Ukrainian Military Medical Academy, Kyiv, Ukraine.
Georgian Medical News
|November 25, 2022
Summary
Fenticonazole shows high sensitivity against Gardnerella vaginalis, a key cause of bacterial vaginosis (BV). This suggests fenticonazole
Area of Science:
- Gynecology
- Microbiology
- Pharmacology
Background:
- Bacterial vaginosis (BV) is a common vaginal infection.
- Gardnerella vaginalis is a primary causative agent of BV.
- Concurrent infections with Candida species can complicate BV treatment.
Purpose of the Study:
- To assess the sensitivity of Gardnerella vaginalis to fenticonazole.
- To evaluate the feasibility of using fenticonazole for treating BV caused by Gardnerella vaginalis and Candida spp.
Main Methods:
- Observation of 98 women aged 20-49 with urogenital tract infections.
- Laboratory analysis of vaginal discharge to identify pathogens.
- In vitro sensitivity testing of Gardnerella vaginalis to fenticonazole.
Main Results:
- Gardnerella vaginalis was detected in 36% of examined women.
- High sensitivity to fenticonazole was observed in 61.2% of Gardnerella vaginalis isolates.
- Low sensitivity was found in 36.1%, and resistance in only 2.7%.
Conclusions:
- Gardnerella vaginalis demonstrates significant sensitivity to fenticonazole.
- Fenticonazole is a potential therapeutic option for local BV treatment, especially in mixed infections.
- Using fenticonazole in complex BV therapy may improve patient compliance.
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