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PECULIARITIES OF MIR-146A AND MIR-155 EXPRESSION IN PATIENTS WITH ALLERGOPATHY IN COMBINATION WITH CHRONIC

S Zubchenko1, S Maruniak2, S tYuriev3

  • 11Danylo Halytsky Lviv National Medical University, Lviv.

Georgian Medical News
|July 20, 2019
PubMed

Insights

Epstein-Barr virus (EBV) infection impacts microRNA levels, potentially worsening allergies. Both active and latent EBV phases showed increased miR-146a, while miR-155 elevated in active EBV, correlating with allergy severity.

Area of Science:

  • Immunology
  • Virology
  • Molecular Biology

Background:

  • Epstein-Barr virus (EBV) persists lifelong, alternating between active and latent phases.
  • EBV disrupts microRNA expression, affecting immune regulation and potentially contributing to conditions like allergopathy.
  • MicroRNAs (miRs) play a crucial role in immune system function and disease pathogenesis.

Purpose of the Study:

  • To investigate the expression levels of miR-146a and miR-155 in patients with allergopathy.
  • To compare these microRNA levels between active and latent phases of EBV infection in individuals with allergopathy.

Main Methods:

  • Clinical, laboratory, cytological, instrumental, allergological, and molecular-genetic investigations were conducted.
  • Patients were categorized into groups based on allergopathy status and EBV phase (active or latent).
  • Expression levels of miR-146a and miR-155 were quantified and compared between groups.

Main Results:

  • Both active and latent EBV phases in allergopathy patients showed significantly higher miR-146a expression compared to healthy controls.
  • miR-155 expression was significantly elevated in patients with active EBV and allergopathy compared to controls.
  • No significant differences in miR-146a or miR-155 expression were observed between the active and latent EBV groups.

Conclusions:

  • EBV infection, in both active and latent phases, is associated with altered microRNA expression (miR-146a and miR-155).
  • The increase in miR-155 expression during the active EBV phase intensifies, correlating with acute allergopathy manifestations.
  • EBV employs specific latency mechanisms involving microRNA upregulation to evade immune surveillance.

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