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Updated: Jan 22, 2026

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis
Published on: July 11, 2025
Acid Fasting: Modulation of Mycobacterium tuberculosis Metabolism at Acidic pH
Jacob J Baker1, Shelby J Dechow1, Robert B Abramovitch1
1Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
Abstract:
Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often attenuated during macrophage or animal infections, supporting that these pathways are essential for pathogenesis and represent important new targets for drug discovery. This review examines a confluence of findings supporting that Mtb has restricted metabolism at acidic pH that results in the slowing of bacterial growth and changes in redox homeostasis. It is proposed that induction of the PhoPR regulon and anaplerotic metabolism, in concert with the restricted use of specific carbon sources, functions to counter reductive stress associated with acidic pH.
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