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A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats
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Eye position-dependent opsoclonus in mild traumatic brain injury
John-Ross Rizzo1, Todd E Hudson1, Alexandra J Sequeira2
1Department of Physical Medicine and Rehabilitation, New York University School of Medicine, New York, NY, United States; Department of Neurology, New York University School of Medicine, New York, NY, United States.
Progress in Brain Research
|July 22, 2019
Summary
Opsoclonus, involuntary rapid eye movements, can occur after head injury. This case study details an unusual presentation linked to post-concussive symptoms, suggesting a potential brain-eye connection.
Area of Science:
- Neuroscience
- Ophthalmology
- Neurology
Background:
- Opsoclonus is characterized by rapid, involuntary, multidirectional saccadic eye movements.
- The exact mechanisms underlying opsoclonus, particularly in the context of traumatic brain injury, remain incompletely understood.
Observation:
- A 60-year-old male presented with post-concussive symptoms including headaches and disequilibrium.
- The patient exhibited small-amplitude opsoclonus in left gaze and larger-amplitude flutter during convergence.
- Video-oculography confirmed opsoclonus, primarily in left gaze and left hemifield pursuit, which resolved with symptom improvement.
Findings:
- The observed opsoclonus demonstrated eye position-dependence, a feature not fully explained by current theories.
- The convergence flutter may represent a related post-traumatic ocular oscillation.
Implications:
- This case suggests a potential link between traumatic brain injury, specific eye movement disorders like opsoclonus, and neurological recovery.
- Further research into the neural correlates of eye position-dependent opsoclonus is warranted.
- Understanding these mechanisms could inform the diagnosis and management of ocular oscillations following head trauma.
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