Related Experiment Video
Updated: Jan 21, 2026
05:06
A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
12.8K
Sequence and Observer Variability in Gadoxectic Acid-Enhanced MRI Lesion Measurements in Hepatocellular Carcinoma
J T J van Lunenburg1, V Tripathi2, V S H Chan3
1Department of Radiology, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Academic Radiology
|July 22, 2019
Summary
This study found high reliability in measuring hepatocellular carcinoma (HCC) on MRI scans across different observers and sequences. While minor differences exist based on experience, arterial phase imaging is reliable for accurate HCC measurements.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Hepatocellular carcinoma (HCC) measurement on MRI is crucial for treatment response assessment.
- Variability in HCC measurements can impact clinical decisions.
- Standardized measurement protocols are essential for reliable HCC assessment.
Purpose of the Study:
- To investigate interobserver and intersequence variability in measuring hepatocellular carcinoma (HCC) using magnetic resonance imaging (MRI).
- To assess the impact of reviewer experience and MRI sequences on HCC size measurements.
- To evaluate measurement agreement using intraclass correlation coefficients.
Main Methods:
- Retrospective analysis of 20 treatment-naïve HCC lesions in 20 patients.
- Measurements performed by six reviewers with varying experience on eight MRI sequences (including Gadoxetic Acid enhanced scans).
- Two measurement methods (SLD and product of diameters) used, analyzed with intraclass correlation coefficients.
Main Results:
- High interobserver and intersequence reliability observed, with intraclass correlation coefficients > 0.95.
- Minor, clinically insignificant differences in measurements between observers based on experience.
- Arterial and hepatobiliary phase images showed similar mean dimensions; diffusion-weighted images had the highest rate of unmeasured lesions (7%).
Conclusions:
- High interobserver and intersequence reliability in HCC measurements on MRI.
- Arterial phase imaging is reliable for HCC measurement, even with indistinct margins.
- Diffusion-weighted MRI sequences are more prone to missing HCC lesions.
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