Comprehensive backscattering characteristics analysis for quantitative ultrasound with an annular array: a basic...

Area of Science:

• Biomedical Engineering
• Medical Imaging
• Acoustics

Background:

• High-frequency ultrasound (HFU) and quantitative ultrasound (QUS) analyze anatomical and acoustic properties.
• Previous HFU research demonstrated noninvasive diagnostic potential via acoustic scattering analysis.
• Limited depth of field (DOF) of conventional HFU transducers restricts QUS analysis range.

Purpose of the Study:

• To enhance HFU and QUS parameter accuracy using an annular array for an extended DOF.
• To investigate envelope statistics and frequency-based analysis with improved DOF.
• To assess the stability and range of QUS analysis with the new transducer.

Main Methods:

• Utilized a 20-MHz, five-element annular-array transducer for signal acquisition.
• Employed post-processing beamforming techniques on acquired signals.
• Scanned two low-concentration scattering phantoms with a 30-μm step size.
• Applied two QUS analysis methods: Nakagami distribution and reflector method.

Main Results:

• The annular array facilitated a stable QUS analysis across an extended axial range.
• Demonstrated improved accuracy in HFU and QUS parameters due to extended DOF.
• Confirmed the effectiveness of the annular array for enhanced noninvasive diagnostic capabilities.

Conclusions:

• Annular array HFU with extended DOF significantly improves QUS analysis stability and range.
• This approach offers enhanced noninvasive diagnostic potential for various medical applications.
• Further research can leverage this technology for more precise anatomical and acoustic characterization.