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ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling

Panpan Hou1,2,3, Jingyi Shi1,2,3, Kelli McFarland White1,2,3

  • 1Department of Biomedical Engineering, Washington University, St. Louis, United States.

Elife
|July 23, 2019
PubMed

Keywords:
KCNQ1 channelML277VSD-pore couplingactivated open statelong QT syndromemolecular biophysicsstate-dependent activationstructural biologyxenopus

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