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Antifungal resistance in dermatophytes: Recent trends and therapeutic implications

Ananta Khurana1, Kabir Sardana1, Anuradha Chowdhary2

  • 1Department of Dermatology, Postgraduate Institute of Medical Education and Research, Dr Ram Manohar Lohia Hospital, New Delhi 110001, India.

Fungal Genetics and Biology : FG & B
|July 23, 2019
PubMed

Insights

Recalcitrant dermatophyte infections, or tinea, are increasing globally. This review examines antifungal drug resistance in dermatophytes and highlights knowledge gaps for future research.

Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Dermatophytoses (tinea) are superficial fungal infections.
  • Recalcitrant cases of tinea corporis and cruris are becoming more prevalent worldwide.
  • Understanding antifungal resistance is crucial for effective treatment.

Purpose of the Study:

  • To review in-vitro and in-vivo antifungal resistance in dermatophytes.
  • To discuss pharmacokinetic properties of systemic antifungal drugs.
  • To explore mechanisms of drug resistance and research gaps.

Main Methods:

  • Comprehensive literature review of antifungal resistance in dermatophytes.
  • Analysis of in-vitro and in-vivo studies.
  • Inclusion of skin pharmacokinetics of systemic antifungals.

Main Results:

  • Dermatophyte resistance to antifungals is a growing concern.
  • Mechanisms of drug resistance are discussed.
  • Discrepancies between in-vitro and in-vivo resistance data are presented.

Conclusions:

  • Further research is needed to address antifungal resistance in dermatophytoses.
  • Understanding drug resistance mechanisms and in-vivo correlations is essential.
  • Future research should focus on improving treatment strategies for recalcitrant tinea.
Keywords:
CorporisCrurisDermatophyteRecalcitrantResistanceTineaTreatment

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