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Related Concept Videos

Classifying Matter by State02:49

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Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, water, soil, mountains, even our bodies are all examples of matter. Matter is divided into three states — solid, liquid, and gas — that are commonly found on earth. The fourth state of matter, plasma, occurs naturally in the interiors of stars. 
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Matter: Pure Substances and Mixtures
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The earliest recorded discussion of the basic structure of matter comes from ancient Greek philosophers. Leucippus and Democritus argued that all matter was composed of small, finite particles that they called atomos, meaning “indivisible.” Later, Aristotle and others came to the conclusion that matter consisted of various combinations of the four “elements” — fire, earth, air, and water — and could be infinitely divided. Interestingly, these philosophers...
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Related Experiment Video

Updated: Jan 21, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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Does Provider Specialty Matter?

Jeannie M Stubblefield1, Mary V Lasley2,3,4,5, Frank S Virant2,3,4,5

  • 1Department of Laboratory Medicine, University of Washington, Seattle.

American Journal of Clinical Pathology
|July 24, 2019
PubMed
Summary

Many allergy tests are ordered unnecessarily, leading to potential misdiagnosis. This study offers a framework to analyze allergy testing patterns and improve their effectiveness, ensuring better patient care.

Keywords:
AllergenAllergy testingIgE testingImmunoassayImmunologyPediatricTest utilization

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Area of Science:

  • Allergy and Immunology
  • Clinical Pathology
  • Health Services Research

Background:

  • Practice guidelines recommend against broad panels of allergen-specific IgE (sIgE) tests due to risks of false positives and misinterpretation.
  • Improving the utilization of diagnostic tests is crucial for effective patient management and healthcare resource allocation.

Purpose of the Study:

  • To develop an analytical framework for identifying specialty-specific differences in allergen-specific IgE (sIgE) test ordering patterns and effectiveness.
  • To provide insights for improving the appropriate utilization of sIgE testing in clinical practice.

Main Methods:

  • Analysis of test results from a tertiary pediatric hospital, stratified by ordering specialty.
  • Evaluation of allergen workup sizes and positivity rates to assess test effectiveness.
  • Examination of laboratory test menu components.

Main Results:

  • Twenty-nine percent of sIgE tests were ordered as part of broad workups (more than 20 tests per date of service), contradicting recommended practices.
  • Detailed data on ordering patterns and positivity rates are presented, highlighting areas for improvement.
  • Specialty-specific differences in test ordering and effectiveness were identified.

Conclusions:

  • The study presents a viable analytical framework for assessing diagnostic test utilization patterns.
  • This approach can be applied to evaluate laboratory testing menus and optimize test selection.
  • Implementing such frameworks can lead to more judicious use of sIgE tests and improved diagnostic accuracy.