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Insulin resistance and pseudoacromegaly: A case report
Leila Moradi1, Fatemeh Amiri1, Hajieh Shahbazian1
1Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Diabetes & Metabolic Syndrome
|July 25, 2019
Summary
Pseudoacromegaly mimics acromegaly symptoms but has normal growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels. This rare condition presents with insulin resistance and acromegaloid features, requiring careful diagnosis.
Area of Science:
- Endocrinology
- Internal Medicine
Background:
- Acromegaly, characterized by soft tissue overgrowth, is typically caused by pituitary adenomas leading to excess growth hormone (GH) and insulin-like growth factor-I (IGF-I).
- The metabolic and somatic features of acromegaly are directly linked to elevated GH and IGF-I levels.
Observation:
- A case of 'pseudoacromegaly' is presented, exhibiting acromegaloid features.
- This condition is distinguished by suppressed IGF-I levels and significantly elevated serum insulin.
Findings:
- The primary finding is the presentation of pseudoacromegaly, a condition that mimics acromegaly clinically.
- Key biochemical markers in this case were normal GH and IGF-I levels, contrasting with marked insulin elevation.
Implications:
- Endocrinologists should consider pseudoacromegaly in patients presenting with acromegaly-like features and insulin resistance, especially when GH and IGF-I are not elevated.
- This highlights the importance of a comprehensive diagnostic approach beyond standard acromegaly markers.
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