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Hyperpigmented Mycosis Fungoides - A Rare Entity.
Anamaria Balić, Sandra Jerković Gulin, Romana Čeović
1Jaka Radoš, MD, University Hospital Centre Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia; sodarakaj@yahoo.com.
Acta Dermatovenerologica Croatica : ADC
|July 29, 2019
Summary
This case report details a rare instance of hyperpigmented mycosis fungoides (MF), a skin lymphoma variant. Diagnosis involved clinical, histopathological, and immunohistochemical analysis, highlighting its rarity and the need for specialized follow-up.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Mycosis fungoides (MF) is a cutaneous T-cell lymphoma.
- Hyperpigmented MF is an uncommon clinical variant, often affecting individuals with darker skin phenotypes.
- Early diagnosis and treatment are crucial for managing MF variants.
Observation:
- A 67-year-old male presented with generalized hyperpigmented patches and plaques, diagnosed as melanoerythroderma.
- Histopathology revealed atypical T-lymphocytes, epidermotropism, Pautrier's microabscesses, and pigment incontinence.
- Immunophenotyping showed a CD4+CD7-CD8+ T-cell phenotype.
Findings:
- The patient was diagnosed with hyperpigmented mycosis fungoides (MF) stage IIIA.
- Skin-directed therapy (retinoids-PUVA) provided slight improvement.
- The case underscores the diagnostic challenges and varied presentations of MF.
Implications:
- This report contributes to the limited literature on hyperpigmented MF, aiding in understanding its pathophysiology.
- Recognizing this rare variant is vital for appropriate patient management and prognosis.
- Further research into the mechanisms of hyperpigmentation in MF is warranted.
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