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Updated: Jan 21, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
Published on: June 26, 2020
Click and photo-release dual-functional nucleic acid nanostructures
Vibhav A Valsangkar1, Arun Richard Chandrasekaran2, Lifeng Zhuo2
1The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA. arun@albany.edu khalvorsen@albany.edu and Department of Chemistry, University at Albany, State University of New York, Albany, NY 12222, USA. jsheng@albany.edu.
Abstract:
We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.
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