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Updated: Jan 21, 2026

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices
Published on: April 1, 2016
Tissue Papers: Leveraging Paper-Based Microfluidics for the Next Generation of 3D Tissue Models
Sabrina M Cramer1, Tyler S Larson1, Matthew R Lockett1,2
1Department of Chemistry , University of North Carolina at Chapel Hill , Kenan and Caudill Laboratories, Chapel Hill , North Carolina 27599-3290 , United States.
Abstract:
Paper-based scaffolds support the three-dimensional culture of mammalian cells in tissue-like environments. These Tissue Papers, a name that highlights the use of materials obtained from (plant) tissue to generate newly functioning (human) tissue structures, are a promising analytical tool to quantify cellular responses in physiologically relevant extracellular gradients and coculture architectures. Here, we highlight current examples of Tissue Papers, commonly used methods of analysis, and current measurement challenges.
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