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Updated: Jan 21, 2026

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
Published on: January 15, 2018
Diselenium-containing ultrathin polymer nanocapsules for highly efficient targeted drug delivery and combined
Shuang Fu1, Fei Li1, Mingsong Zang1
1State Key Laboratory of Supramolecular Structure and Materials, Collage of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. junqiuliu@jlu.edu.cn xujianyun@jlu.edu.cn.
Abstract:
The combination of selenium and pillararenes to prepare selenium-containing pillararene-based biomaterials is of great significance for the development of biomedicine. Herein, using a covalent self-assembly strategy, we successfully developed new diselenium-containing ultrathin polymer nanocapsules based on lateral cross-linked pillararenes. The new system exhibited a very potent anticancer effect; additionally, the incorporation of the cleavable redox diselenium bond into the polymer nanocapsules provided a smart nanocarrier for drug delivery. Moreover, the polymer nanocapsules were developed for anticancer drug targeting delivery by loading an anticancer drug and introducing the tumor-penetrating peptide RGD through the host-guest interaction strategy. The targeting DOX-loaded diselenium-containing polymer nanocapsules exhibited enhanced stability, self-anticancer effect, targeted delivery and controlled drug release, resulting in effective combined inhibition of tumor progression.
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