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Salivary Eosinophil Cationic Protein in Allergic Rhinitis
Tolga Kırgezen1, Ela Araz Server1, Fulya Savran Turanoğlu1
1Department of Otorhinolaryngology, İstanbul Training and Research Hospital, İstanbul, Turkey.
Turkish Archives of Otorhinolaryngology
|July 31, 2019
Summary
Saliva eosinophil cationic protein (ECP) levels do not correlate with allergic rhinitis (AR) diagnosis. This study found no significant difference in salivary ECP between AR patients and healthy individuals, suggesting it
Area of Science:
- Immunology
- Allergology
- Biochemistry
Background:
- Eosinophil cationic protein (ECP) is implicated in allergic rhinitis (AR) and asthma pathogenesis.
- Saliva offers a non-invasive method for diagnostic analysis.
- Previous studies suggest salivary ECP analysis may aid asthma diagnosis.
Purpose of the Study:
- To investigate the association between salivary ECP levels and allergic rhinitis (AR) diagnosis.
- To compare salivary ECP levels with serum ECP levels in AR patients and healthy controls.
Main Methods:
- Recruited 35 AR patients (sensitive to Dermatophagoides farinae) and 35 healthy controls.
- Measured salivary ECP, serum ECP, and serum specific IgE D2 levels.
- Utilized skin prick testing (SPT) for patient stratification.
Main Results:
- No significant differences in salivary or serum ECP levels were observed between AR patients and controls.
- Serum specific IgE D2 levels were significantly higher in the AR group.
- No significant correlation was found between salivary and serum ECP levels in either group.
Conclusions:
- Salivary ECP levels are comparable to serum ECP levels but do not correlate with them.
- Salivary ECP is not a helpful diagnostic marker for allergic rhinitis (AR).
- Further research may explore other non-invasive biomarkers for AR diagnosis.
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