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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

926
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Curing of Concrete01:20

Curing of Concrete

354
The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
354
Curing Methods01:26

Curing Methods

284
Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
284
Accelerated Curing of Concrete01:25

Accelerated Curing of Concrete

454
Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...
454
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

2.0K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
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Related Experiment Video

Updated: Jan 21, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
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Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

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Can ulcerative colitis be cured?

Jay Pravda1

  • 1Therashock LLC, #247 Northlake Blvd., Palm Beach Gardens, FL 33410, USA.

Discovery Medicine
|July 31, 2019
PubMed
Summary

Hydrogen peroxide produced by colon cells plays a causal role in ulcerative colitis (UC) development. Elevated hydrogen peroxide levels in non-inflamed colons suggest it precedes inflammation, driving disease onset.

Area of Science:

  • Gastroenterology
  • Immunology
  • Cell Biology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease with significant global impact.
  • Despite extensive research, the primary immune abnormality underlying UC remains elusive.
  • Current understanding points to a potential role for colonocyte-derived factors in UC pathogenesis.

Purpose of the Study:

  • To investigate the role of colonocyte-generated hydrogen peroxide in ulcerative colitis pathogenesis.
  • To explore hydrogen peroxide as a potential initiating factor in the development of UC.
  • To provide an alternative perspective on UC etiology beyond primary immune dysfunction.

Main Methods:

  • Systems pathogenesis analysis to identify key molecular contributors.

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Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
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Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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  • Measurement of hydrogen peroxide levels in colonic mucosa from UC patients.
  • Correlation of hydrogen peroxide levels with disease status (inflamed vs. non-inflamed).

    • Main Results:

    • Significantly elevated hydrogen peroxide levels were found in non-inflamed colonic mucosa of UC patients.
    • These elevated levels suggest a pre-inflammatory build-up of hydrogen peroxide.
    • Hydrogen peroxide's properties facilitate epithelial barrier disruption and inflammatory cell recruitment.

    Conclusions:

    • Colonocyte-generated hydrogen peroxide is implicated as a causal factor in ulcerative colitis development.
    • Hydrogen peroxide may initiate the inflammatory cascade leading to UC.
    • This finding offers a novel therapeutic target for ulcerative colitis.