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Updated: Jan 21, 2026

An Orthotopic Mouse Model of Spontaneous Breast Cancer Metastasis
Published on: August 14, 2016
Skeletal-related adverse events during bone metastasis of breast cancer: current status
Mei Yang1, Chang Liu1, Xijie Yu1
1Laboratory of Endocrinology and Metabolism, Department of Endocrinology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Abstract:
Skeletal-related events are severe problems in patients with breast cancer. Bone metastasis and endocrine therapy are closely related to skeletal morbidity and mortality. Skeletal-related events during breast cancer tumorigenesis lead to the exacerbated poor life quality of patients. This review summarizes recent advances in our understanding of the characteristics of skeletal-related events during bone metastasis of breast cancer, especially on the major cause of skeletal-related events, early diagnosis and threshold of anti-absorption treatment. Finally, we highlight novel approaches for the diagnosis and treatment of skeletal-related events during bone metastasis of breast cancer.
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