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Alternative mRNA splicing in cancer immunotherapy

Luke Frankiw1, David Baltimore2, Guideng Li3,4

  • 1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Nature Reviews. Immunology
|August 1, 2019
PubMed

Insights

Alternative messenger RNA (mRNA) processing in cancer cells offers new targets for cancer immunotherapies. Analyzing mRNA splicing events can broaden the scope of cancer vaccines and T cell therapies for better treatment outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Cancer immunotherapies show promise for treating previously untreatable cancers.
  • Identifying tumor-specific antigens for cancer vaccines and T cell therapies remains a significant challenge.

Purpose of the Study:

  • To explore the potential of analyzing messenger RNA (mRNA) processing events in cancer cells as a source of novel immunotherapy targets.
  • To emphasize the role of mRNA splicing in expanding the target space for cancer immunotherapy.

Main Methods:

  • Review and discussion of current research on mRNA processing in cancer.
  • Focus on the analysis of alternative mRNA splicing events.
  • Evaluation of the potential for clinical application of identified targets.

Main Results:

  • Alternative mRNA processing, particularly splicing, alters cancer proteomic diversity.
  • This phenomenon presents a potential for a broader range of targets for immunotherapy.

Conclusions:

  • Analyzing mRNA splicing in cancer holds promise for identifying new targets for cancer immunotherapy.
  • Overcoming current challenges is crucial for the clinical applicability of this approach.

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