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Related Experiment Video

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Obsessive-Compulsive Disorder: Autoimmunity and Neuroinflammation.

Mona Gerentes1,2, Antoine Pelissolo1,2,3, Krishnamoorthy Rajagopal1

  • 1Inserm U955, Team 15, Genetic Psychiatry, 94000, Creteil, France.

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Obsessive-compulsive disorder (OCD) may involve immune system dysfunction, indicated by inflammation and autoimmune issues. Targeting these immune responses could lead to personalized treatments for OCD patients.

Keywords:
AutoimmunityInfectionsInflammationOCD

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Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Background:

  • Obsessive-compulsive disorder (OCD) is increasingly linked to immune system dysregulation.
  • A significant subset of OCD patients exhibits persistent low-grade inflammation and autoimmune comorbidities.

Purpose of the Study:

  • To review the immuno-inflammatory hypothesis in OCD.
  • To explore the role of immune dysfunction in OCD pathogenesis and treatment.

Main Methods:

  • Literature review of studies on inflammation, autoimmunity, and OCD.
  • Analysis of findings related to inflammatory markers, neural antibodies, and infectious triggers.

Main Results:

  • OCD is associated with low-grade inflammation, neural antibodies, and neuro-inflammatory disorders.
  • Autoimmunity in some OCD patients may be triggered by infections with shared epitopes with the central nervous system (CNS).

Conclusions:

  • Immune system dysfunction is a relevant factor in a subset of OCD patients.
  • Stratifying OCD patients based on immune profiles may enable personalized therapeutic strategies targeting inflammation or infection.