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Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
Published on: August 6, 2019
DNA functionalization of colloidal particles via physisorption of azide-functionalized diblock copolymers
Jeongbin Moon1, In-Seong Jo1, Jeong Hoon Yoon1
1School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea. yigira@skku.edu.
Abstract:
DNA-coated inorganic particles can be prepared simply by physical adsorption of azide-functionalized diblock copolymers (polystyrene-b-poly(ethylene oxide)-azide, PS-b-PEO-N3) onto hydrophobically-modified inorganic particles, followed by strain-promoted azide-alkyne cycloaddition (SPAAC, copper-free click chemistry). This approach is applied to organosilica, silica and titania particles. The DNA-coated colloids are successfully crystallized into colloidal superstructures by a thermal annealing process using DNA-mediated assembly.
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