Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

496
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
496
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

850
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
850
Stages of Sleep01:22

Stages of Sleep

1.3K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.3K
Understanding Sleep01:11

Understanding Sleep

1.4K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.4K
Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

100.2K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
100.2K
Sleepwalking and Sleep Talking01:17

Sleepwalking and Sleep Talking

926
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
926

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Venlafaxine on Apnea-Hypopnea Index in Patients With Sleep Apnea: A Randomized, Double-Blind Crossover Study.

Chest·2020
Same author

Is Umbilical Cord Blood Therapy an Effective Treatment for Early Lung Injury in Growth Restriction?

Frontiers in endocrinology·2020
Same author

Pathogenesis of obstructive sleep apnea in individuals with the COPD + OSA Overlap syndrome versus OSA alone.

Physiological reports·2020
Same author

The Neurovascular Unit: Effects of Brain Insults During the Perinatal Period.

Frontiers in neuroscience·2020
Same author

Cardiovascular consequences of obstructive sleep apnea in women: a historical cohort study.

Sleep medicine·2020
Same author

REM-related obstructive sleep apnea: when does it matter? Effect on motor memory consolidation versus emotional health.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2020
Same journal

Future Research Direction for Women's Sleep Health.

Sleep medicine clinics·2026
Same journal

Sleep Disturbance and Female Infertility.

Sleep medicine clinics·2026
Same journal

Circadian Disruption Shift Work and Breast Cancer Risk.

Sleep medicine clinics·2026
Same journal

Sleep Duration and Mortality in Women: Effect of Aging and Menopause.

Sleep medicine clinics·2026
Same journal

Update on Restless Legs Syndrome Management during Pregnancy.

Sleep medicine clinics·2026
Same journal

Current Evidence on Sleep and Women's Mental Health.

Sleep medicine clinics·2026
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.5K

Precision Medicine for Obstructive Sleep Apnea.

Matthew Light1, Robert L Owens1, Christopher N Schmickl1

  • 1Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, 9300 Campus Point Drive #7381, La Jolla, CA 92037-7381, USA.

Sleep Medicine Clinics
|August 4, 2019
PubMed
Summary
This summary is machine-generated.

Precision medicine is revolutionizing obstructive sleep apnea (OSA) treatment by identifying distinct patient endotypes. Understanding these subtypes improves therapy adherence and predicts health outcomes, paving the way for personalized sleep science insights.

Keywords:
Arousal thresholdLoop gainOSA TreatmentObstructive sleep apneaPrecision medicine

More Related Videos

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

3.4K
Multi-Modal Home Sleep Monitoring in Older Adults
07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

8.1K

Related Experiment Videos

Last Updated: Jan 21, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.5K
Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

3.4K
Multi-Modal Home Sleep Monitoring in Older Adults
07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

8.1K

Area of Science:

  • Sleep Medicine
  • Precision Medicine
  • Respiratory Physiology

Background:

  • Obstructive sleep apnea (OSA) is increasingly viewed through the lens of precision medicine.
  • Beyond anatomical factors, distinct pathophysiologic mechanisms (endotypes) of OSA are being identified.
  • These endotypes can be assessed during polysomnography.

Purpose of the Study:

  • To highlight the potential of a precision medicine approach in obstructive sleep apnea treatment.
  • To emphasize the role of endotypes in predicting treatment adherence and disease phenotypes.
  • To discuss emerging research in biomarker discovery and big data for sleep science.

Main Methods:

  • Identification of distinct pathophysiologic mechanisms (endotypes) in obstructive sleep apnea.
  • Assessment of endotypes using polysomnography.
  • Review of research on endotype-specific therapies, adherence, and disease consequences (phenotypes).

Main Results:

  • Endotypes beyond simple airway anatomy are identifiable in OSA patients.
  • Endotypes show potential for predicting adherence to treatment.
  • Endotypes may also predict OSA-related health consequences (phenotypes).

Conclusions:

  • A precision medicine approach, informed by endotype identification, is crucial for optimizing OSA treatment.
  • Further research, including randomized controlled trials of endotype-specific therapies, is needed.
  • Biomarker discovery and big data analytics, including wearable technology, will enhance understanding and personalized care in sleep science.