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Related Experiment Video

Updated: Jan 21, 2026

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
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Programmable Paper-Based Microfluidic Devices for Biomarker Detections.

Veasna Soum1, Sooyong Park1, Albertus Ivan Brilian1

  • 1Department of Chemistry, Institute of Biological Interfaces, Sogang University, Seoul 04107, Korea.

Micromachines
|August 7, 2019
PubMed
Summary
This summary is machine-generated.

Programmable paper-based microfluidic devices offer automated, sensitive biomarker detection for point-of-care testing. This review explores advances in paper-based continuous-flow (p-CMF) and digital (p-DMF) microfluidics for biomarker analysis.

Keywords:
biomarker detectiondigital microfluidic devicedroplet actuationflow controlmulti-step assaypaper-based microfluidic device

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • Paper-based microfluidic devices offer affordable and portable solutions for point-of-care testing (POCT).
  • Programmable microfluidics enhance control over fluid manipulation, enabling sensitive and automated biomarker detection.
  • Advances in paper-based microfluidics are crucial for developing next-generation diagnostic tools.

Purpose of the Study:

  • To review recent advancements in programmable paper-based microfluidic devices for biomarker detection.
  • To examine fabrication methods and fluid manipulation strategies for paper-based continuous-flow (p-CMF) and paper-based digital microfluidic (p-DMF) devices.
  • To discuss the application of these devices in single- and multi-step biomarker assays and their future outlook.

Main Methods:

  • Review of literature on programmable paper-based microfluidic devices.
  • Analysis of fabrication techniques for p-CMF and p-DMF systems.
  • Examination of fluid programming and droplet manipulation strategies.
  • Assessment of applications in biomarker detection assays.

Main Results:

  • Programmable paper-based microfluidics, including p-CMF and p-DMF, demonstrate high sensitivity and automation for biomarker detection.
  • Various fabrication methods and fluid control strategies enable diverse applications in single- and multi-step assays.
  • These devices show significant potential for accessible and efficient point-of-care diagnostics.

Conclusions:

  • Programmable paper-based microfluidics represent a significant advancement in biomarker detection technology.
  • Further development is needed to address current limitations and fully realize the potential of these devices for widespread POCT.
  • The review highlights the promising future of paper-based microfluidics in personalized and accessible healthcare.